It is possible since the deltaqueues are managed with respect to the target systems. So all the applications that use the delta queue functionality to process deltas are OK. These will include the LO Cockpit, EC-PCA and others.
This functionality will not work for the old LIS datasources (probably not an issue for the client since these have been declared obsolete for many years).
In addition, for datasources that use timestamp functionality (such as in the FI and CO areas as well as generic datasources with timestamps), care must be taken not to execute initializations or delta extractions from different BW systems for the same datasource simultaneously.
OSS notes 775568 and 844222 provide detail on this queston.